The L84F polymorphism in the O6-Methylguanine-DNA-Methyltransferase (MGMT) gene is associated with increased hypoxanthine phosphoribosyltransferase (HPRT) mutant frequency in lymphocytes of tobacco smokers. [electronic resource]
- Pharmacogenetics and genomics Sep 2007
- 743-53 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1744-6872
10.1097/FPC.0b013e3281111eb1 doi
Adult Age Factors Aged Alkylating Agents--toxicity Base Sequence DNA Modification Methylases--genetics DNA Primers--genetics DNA Repair--genetics DNA Repair Enzymes--genetics Female Genotype Humans Hypoxanthine Phosphoribosyltransferase--genetics Lymphocytes--drug effects Male Middle Aged Mutation Pharmacogenetics Polymorphism, Single Nucleotide Smoking--genetics Tumor Suppressor Proteins--genetics