Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling. [electronic resource]
- Annals of oncology : official journal of the European Society for Medical Oncology Aug 2007
- 1323-8 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0923-7534
10.1093/annonc/mdm170 doi
Antineoplastic Agents, Hormonal--pharmacology Antineoplastic Combined Chemotherapy Protocols--pharmacology Apoptosis--drug effects Aromatase Inhibitors--pharmacology Blotting, Western Breast Neoplasms--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Drug Resistance, Neoplasm--physiology Estradiol--analogs & derivatives Everolimus Female Flow Cytometry Fulvestrant Humans Letrozole Nitriles--pharmacology Protein Kinases--drug effects Proto-Oncogene Proteins c-akt--metabolism Sirolimus--analogs & derivatives TOR Serine-Threonine Kinases Triazoles--pharmacology