Attenuated expression of episodic growth hormone-induced CYP2C11 in female rats associated with suboptimal activation of the Jak2/Stat5B and other modulating signaling pathways. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Nov 2007
- 2102-10 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0090-9556
10.1124/dmd.107.017475 doi
Animals Aryl Hydrocarbon Hydroxylases--genetics Blotting, Western Cytochrome P-450 CYP3A Cytochrome P450 Family 2 Female Gene Expression--drug effects Growth Hormone--administration & dosage Hypophysectomy I-kappa B Proteins--metabolism Janus Kinase 2--metabolism Liver--cytology Male Membrane Proteins--genetics Mitogen-Activated Protein Kinases--metabolism NF-KappaB Inhibitor alpha Phosphorylation--drug effects Promoter Regions, Genetic--genetics Protein Binding Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction STAT5 Transcription Factor--metabolism Sex Factors Signal Transduction--drug effects Steroid 16-alpha-Hydroxylase--genetics Steroid Hydroxylases--genetics