Plaza-Menacho, Iván <br/><br/>
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.  [electronic resource] 

 -  The Journal of biological chemistry  Oct 2007 
 - 29230-40 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M703461200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Benzenesulfonates--pharmacology<br/>Cell Line<br/>Cell Line, Tumor<br/>Cell Proliferation<br/>Humans<br/>Inhibitory Concentration 50<br/>Lysosomes--metabolism<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3--metabolism<br/>Multiple Endocrine Neoplasia Type 2a--metabolism<br/>Niacinamide--analogs & derivatives<br/>Phenylurea Compounds<br/>Phosphorylation<br/>Proteasome Endopeptidase Complex--metabolism<br/>Protein Kinase Inhibitors--pharmacology<br/>Proto-Oncogene Proteins B-raf--metabolism<br/>Proto-Oncogene Proteins c-ret--metabolism<br/>Pyridines--pharmacology<br/>Sorafenib