Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Oct 2007
- 102-8 p. digital
Publication Type: Journal Article
0022-3565
10.1124/jpet.107.125492 doi
Amyloid Precursor Protein Secretases--antagonists & inhibitors Amyloid beta-Protein Precursor--biosynthesis Animals Binding Sites Brain--drug effects Dose-Response Relationship, Drug Enzyme Inhibitors--chemistry Ligands Mice Mice, Transgenic Molecular Structure Radioligand Assay Time Factors