XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. [electronic resource]
- Environmental and molecular mutagenesis Jul 2007
- 491-500 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
0893-6692
10.1002/em.20312 doi
Animals BRCA2 Protein--metabolism CHO Cells Cell Extracts Cell Survival--drug effects Chromosomal Instability--drug effects Cricetinae Cricetulus DNA Damage DNA-Binding Proteins--genetics Down-Regulation HeLa Cells Humans Methyl Methanesulfonate--toxicity Micronucleus Tests Mutagens--toxicity Mutation--genetics Neoplasms--pathology RNA, Small Interfering--metabolism Sister Chromatid Exchange--drug effects Transfection X-ray Repair Cross Complementing Protein 1