Smith, Paul A

Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors. [electronic resource] - European journal of pharmacology Oct 2007 - 129-37 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0014-2999

10.1016/j.ejphar.2007.06.001 doi


Analgesics, Non-Narcotic--administration & dosage
Analgesics, Opioid--administration & dosage
Animals
Benzoxazines--pharmacology
Dose-Response Relationship, Drug
Dronabinol--administration & dosage
Drug Synergism
Drug Therapy, Combination
Drug Tolerance
Enkephalin, Ala(2)-MePhe(4)-Gly(5)---pharmacology
Guanosine 5'-O-(3-Thiotriphosphate)--metabolism
Injections, Intraperitoneal
Injections, Subcutaneous
Male
Morphine--administration & dosage
Morpholines--pharmacology
Naphthalenes--pharmacology
Pain--metabolism
Pain Measurement
Pain Threshold--drug effects
Periaqueductal Gray--drug effects
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1--agonists
Receptors, Opioid, mu--agonists
Spinal Cord--drug effects
Sulfur Radioisotopes
Time Factors