TY  - GEN
AU  - Doherty,Elizabeth M
AU  - Fotsch,Christopher
AU  - Bannon,Anthony W
AU  - Bo,Yunxin
AU  - Chen,Ning
AU  - Dominguez,Celia
AU  - Falsey,James
AU  - Gavva,Narender R
AU  - Katon,Jodie
AU  - Nixey,Thomas
AU  - Ognyanov,Vassil I
AU  - Pettus,Liping
AU  - Rzasa,Robert M
AU  - Stec,Markian
AU  - Surapaneni,Sekhar
AU  - Tamir,Rami
AU  - Zhu,Jiawang
AU  - Treanor,James J S
AU  - Norman,Mark H
TI  - Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate
SN  - 0022-2623
PY  - 2007///1015
KW  - Analgesics
KW  - chemical synthesis
KW  - Animals
KW  - Benzothiazoles
KW  - CHO Cells
KW  - Calcium
KW  - metabolism
KW  - Cricetinae
KW  - Cricetulus
KW  - Dogs
KW  - Drug Stability
KW  - Haplorhini
KW  - Humans
KW  - Hyperalgesia
KW  - drug therapy
KW  - In Vitro Techniques
KW  - Inflammation
KW  - Male
KW  - Microsomes, Liver
KW  - Pain Measurement
KW  - Pyrimidines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Solubility
KW  - Structure-Activity Relationship
KW  - TRPV Cation Channels
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm070190p
ER  -