MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. [electronic resource]
- Blood Sep 2007
- 2092-101 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
0006-4971
10.1182/blood-2007-04-083204 doi
Antineoplastic Agents--pharmacology Apoptosis--drug effects Apoptosis Regulatory Proteins--antagonists & inhibitors Bcl-2-Like Protein 11 Benzamides--pharmacology Blotting, Western Drug Synergism Enzyme Inhibitors--pharmacology Humans Immunoprecipitation Insulin-Like Growth Factor I--pharmacology Interleukin-6--pharmacology MAP Kinase Kinase 1--antagonists & inhibitors MAP Kinase Kinase 2--antagonists & inhibitors Membrane Proteins--antagonists & inhibitors Multiple Myeloma--drug therapy Phosphorylation--drug effects Protein Conformation Protein Kinase C--antagonists & inhibitors Protein Transport Proto-Oncogene Proteins--antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2--metabolism RNA, Small Interfering--pharmacology Staurosporine--analogs & derivatives Subcellular Fractions bcl-2 Homologous Antagonist-Killer Protein--metabolism bcl-2-Associated X Protein--metabolism bcl-X Protein--metabolism