TY - GEN AU - Lalonde,R L AU - Kowalski,K G AU - Hutmacher,M M AU - Ewy,W AU - Nichols,D J AU - Milligan,P A AU - Corrigan,B W AU - Lockwood,P A AU - Marshall,S A AU - Benincosa,L J AU - Tensfeldt,T G AU - Parivar,K AU - Amantea,M AU - Glue,P AU - Koide,H AU - Miller,R TI - Model-based drug development SN - 0009-9236 PY - 2007///0816 KW - Alzheimer Disease KW - drug therapy KW - Amines KW - pharmacology KW - Analgesics KW - Animals KW - Anticholesteremic Agents KW - Bridged Bicyclo Compounds, Heterocyclic KW - Caproates KW - Cholesterol KW - blood KW - Clinical Trials as Topic KW - legislation & jurisprudence KW - Cognition KW - drug effects KW - Computer Simulation KW - Cyclohexanecarboxylic Acids KW - Dose-Response Relationship, Drug KW - Drug Approval KW - Drug Design KW - Gabapentin KW - Glycoproteins KW - Guidelines as Topic KW - Humans KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Hypercholesterolemia KW - Immunologic Factors KW - Meta-Analysis as Topic KW - Models, Biological KW - Models, Statistical KW - Muscarinic Agonists KW - Neuralgia, Postherpetic KW - Neutrophil Infiltration KW - Oximes KW - Pharmacokinetics KW - Pharmacology KW - Reproducibility of Results KW - Research Design KW - Stroke KW - United States KW - United States Food and Drug Administration KW - gamma-Aminobutyric Acid N1 - Publication Type: Journal Article; Review UR - https://doi.org/10.1038/sj.clpt.6100235 ER -