Lwin, Tint

Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. [electronic resource] - Blood Sep 2007 - 1631-8 p. digital

Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2006-11-060350 doi


Anaphase-Promoting Complex-Cyclosome
Antigens, CD
Bone Marrow Cells--metabolism
Cadherins--genetics
Cell Adhesion--drug effects
Cell Line, Tumor
Cyclin-Dependent Kinase Inhibitor p21--genetics
Cyclin-Dependent Kinase Inhibitor p27
G1 Phase--drug effects
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lymphoma, B-Cell--enzymology
Lymphoma, Mantle-Cell--enzymology
Models, Biological
Neoplasm Proteins--antagonists & inhibitors
Proteasome Endopeptidase Complex--genetics
RNA, Small Interfering--metabolism
S-Phase Kinase-Associated Proteins--antagonists & inhibitors
Signal Transduction--drug effects
Stromal Cells--metabolism
Ubiquitin--genetics
Ubiquitin-Protein Ligase Complexes--genetics