Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. [electronic resource]
- The Journal of biological chemistry Jul 2007
- 20534-43 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M611782200 doi
Amino Acid Motifs--genetics Animals Antibiotics, Antineoplastic--pharmacology Cell Hypoxia--drug effects Cell Line, Tumor Guanine Nucleotides--metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit--genetics Mice Monomeric GTP-Binding Proteins--genetics Mutation, Missense Neoplasms--drug therapy Neovascularization, Pathologic--drug therapy Neuropeptides--genetics Protein Binding--drug effects Protein Kinases--genetics Protein Structure, Tertiary--drug effects Ras Homolog Enriched in Brain Protein Signal Transduction--drug effects Sirolimus--pharmacology TOR Serine-Threonine Kinases Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins--genetics Vascular Endothelial Growth Factor A--genetics Von Hippel-Lindau Tumor Suppressor Protein--genetics p300-CBP Transcription Factors--genetics