AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. [electronic resource]
- Blood Sep 2007
- 2034-40 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2007-02-073700 doi
Animals Antibiotics, Antineoplastic--pharmacology Apoptosis--drug effects Aurora Kinase A Aurora Kinase B Aurora Kinases Case-Control Studies Cell Cycle--drug effects Cell Proliferation--drug effects Colony-Forming Units Assay Daunorubicin--pharmacology Drug Synergism Drug Therapy, Combination Drug Tolerance Enzyme Inhibitors--pharmacology Female Flow Cytometry Humans Immunoblotting Leukemia--drug therapy Mice Mice, Inbred BALB C Organophosphates--pharmacology Protein Serine-Threonine Kinases--antagonists & inhibitors Quinazolines--pharmacology Thymidine--metabolism Transplantation, Heterologous Tubulin Modulators--pharmacology Vincristine--pharmacology