TY - GEN AU - Clemmons,D R AU - Cascieri,M A AU - Camacho-Hubner,C AU - McCusker,R H AU - Bayne,M L TI - Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity SN - 0021-9258 PY - 1990///0830 KW - Amino Acid Sequence KW - Animals KW - Binding, Competitive KW - Carrier Proteins KW - metabolism KW - Cells, Cultured KW - DNA KW - biosynthesis KW - DNA Mutational Analysis KW - Humans KW - In Vitro Techniques KW - Insulin-Like Growth Factor Binding Proteins KW - Insulin-Like Growth Factor I KW - Molecular Sequence Data KW - Protein Conformation KW - Receptors, Cell Surface KW - Receptors, Somatomedin KW - Somatomedins KW - Structure-Activity Relationship KW - Swine N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S ER -