Warner, Nadia <br/><br/>
The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.  [electronic resource] 

 -  Antimicrobial agents and chemotherapy  Jul 2007 
 - 2285-92 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0066-4804 
<br/><br/><label>Standard No.: </label>10.1128/AAC.01499-06  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Motifs<br/>Amino Acid Sequence<br/>Amino Acid Substitution<br/>Binding Sites<br/>Carcinoma, Hepatocellular--pathology<br/>Cell Line, Tumor<br/>Conserved Sequence<br/>DNA-Directed DNA Polymerase--chemistry<br/>Drug Resistance, Viral<br/>Hepatitis B virus--drug effects<br/>Humans<br/>In Vitro Techniques<br/>Lamivudine--pharmacology<br/>Liver Neoplasms--pathology<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Mutagenesis, Site-Directed<br/>Protein Structure, Secondary<br/>Protein Structure, Tertiary<br/>Reverse Transcriptase Inhibitors--pharmacology<br/>Sequence Homology, Amino Acid<br/>Virus Replication