Ghosh, Arun K <br/><br/>
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.  [electronic resource] 

 -  Journal of medicinal chemistry  May 2007 
 - 2399-407 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm061338s  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amides--chemical synthesis<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Peptides--antagonists & inhibitors<br/>Animals<br/>Aspartic Acid Endopeptidases--antagonists & inhibitors<br/>Binding Sites<br/>CHO Cells<br/>Cricetinae<br/>Cricetulus<br/>Crystallography, X-Ray<br/>Dipeptides--chemistry<br/>Drug Design<br/>Female<br/>Ligands<br/>Mice<br/>Mice, Transgenic<br/>Models, Molecular<br/>Molecular Structure<br/>Peptide Fragments--antagonists & inhibitors<br/>Phthalic Acids--chemical synthesis<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Sulfonamides--chemical synthesis<br/>Valine--analogs & derivatives