TY - GEN AU - van Tijn,Paula AU - de Vrij,Femke M S AU - Schuurman,Karianne G AU - Dantuma,Nico P AU - Fischer,David F AU - van Leeuwen,Fred W AU - Hol,Elly M TI - Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease SN - 0021-9533 PY - 2007///1002 KW - Animals KW - Blotting, Western KW - Cerebral Cortex KW - drug effects KW - Cysteine Proteinase Inhibitors KW - pharmacology KW - Cytosol KW - metabolism KW - Dose-Response Relationship, Drug KW - Doxorubicin KW - Flow Cytometry KW - Frameshift Mutation KW - Gene Expression KW - Green Fluorescent Proteins KW - genetics KW - HeLa Cells KW - Humans KW - Leupeptins KW - Mice KW - Mice, Inbred C57BL KW - Mice, Transgenic KW - Models, Biological KW - Neurodegenerative Diseases KW - Oligopeptides KW - Proteasome Endopeptidase Complex KW - Proteasome Inhibitors KW - Tissue Culture Techniques KW - Transfection KW - Ubiquitin N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1242/jcs.03438 ER -