Odièvre, Marie-Hélène Sodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: relevance to sickle-cell disease. [electronic resource] - American journal of hematology May 2007 - 357-62 p. digital Publication Type: Journal Article ISSN: 0361-8609 Standard No.: 10.1002/ajh.20709 doi Subjects--Topical Terms: Anemia, Sickle Cell--drug therapyCell Line, Transformed--drug effectsDrug Evaluation, PreclinicalDrug SynergismEndothelial Cells--drug effectsEndothelin-1--biosynthesisGene Expression Regulation--drug effectsHumansHydroxyurea--pharmacologyIntercellular Adhesion Molecule-1--biosynthesisInterferon-gamma--pharmacologyPhenylbutyrates--pharmacologyRNA, Messenger--biosynthesisSolubilityTumor Necrosis Factor-alpha--pharmacologyVascular Cell Adhesion Molecule-1--biosynthesis