The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. [electronic resource]
- The Journal of biological chemistry May 2007
- 15271-83 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
0021-9258
10.1074/jbc.M701362200 doi
Anthracenes--pharmacology Antibiotics, Antineoplastic--pharmacology Apoptosis--drug effects Breast Neoplasms--drug therapy Caspases--metabolism Cell Line, Tumor Doxorubicin--pharmacology Drug Resistance, Multiple--drug effects Drug Resistance, Neoplasm--drug effects Drug Screening Assays, Antitumor Enzyme Activation--drug effects Enzyme Inhibitors--pharmacology Female Gene Expression Regulation, Enzymologic--drug effects Gene Expression Regulation, Leukemic--drug effects Humans JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Lamin Type A--metabolism MAP Kinase Kinase 4--antagonists & inhibitors Neoplasm Proteins--metabolism Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases--metabolism Protein Kinase C-delta--metabolism Protein Processing, Post-Translational--drug effects Pyrimidine Nucleosides--pharmacology