TY  - GEN
AU  - Tao,Zhi-Fu
AU  - Wang,Le
AU  - Stewart,Kent D
AU  - Chen,Zehan
AU  - Gu,Wendy
AU  - Bui,Mai-Ha
AU  - Merta,Philip
AU  - Zhang,Haiying
AU  - Kovar,Peter
AU  - Johnson,Eric
AU  - Park,Chang
AU  - Judge,Russell
AU  - Rosenberg,Saul
AU  - Sowin,Thomas
AU  - Lin,Nan-Horng
TI  - Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors
SN  - 0022-2623
PY  - 2007///0514
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Camptothecin
KW  - pharmacology
KW  - Cell Line, Tumor
KW  - Checkpoint Kinase 1
KW  - Crystallography, X-Ray
KW  - DNA Damage
KW  - Doxorubicin
KW  - Drug Design
KW  - Drug Screening Assays, Antitumor
KW  - Drug Synergism
KW  - Humans
KW  - Macrocyclic Compounds
KW  - Models, Molecular
KW  - Protein Kinase Inhibitors
KW  - Protein Kinases
KW  - chemistry
KW  - Structure-Activity Relationship
KW  - Urea
KW  - analogs & derivatives
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm061247v
ER  -