Saussele, T
Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. [electronic resource]
- Clinical pharmacology and therapeutics Sep 2007
- 265-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
ISSN: 0009-9236
Standard No.: 10.1038/sj.clpt.6100138 doi
Subjects--Topical Terms: Aged Anti-Inflammatory Agents, Non-Steroidal--pharmacology Aryl Hydrocarbon Hydroxylases--biosynthesis Blotting, Western Catalysis Cells, Cultured Constitutive Androstane Receptor Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System--biosynthesis DNA--biosynthesis Dipyrone--analogs & derivatives Dose-Response Relationship, Drug Enzyme Induction--drug effects Female Genotype Hepatocytes--drug effects Humans In Vitro Techniques Isoenzymes--metabolism Liver--drug effects Male Microsomes, Liver--drug effects Middle Aged Oxidoreductases, N-Demethylating--biosynthesis Plasmids Pregnane X Receptor RNA--biosynthesis Receptors, Cytoplasmic and Nuclear--drug effects Receptors, Steroid--drug effects Reverse Transcriptase Polymerase Chain Reaction Transcription Factors--drug effects