Saussele, T

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. [electronic resource] - Clinical pharmacology and therapeutics Sep 2007 - 265-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0009-9236

10.1038/sj.clpt.6100138 doi


Aged
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Aryl Hydrocarbon Hydroxylases--biosynthesis
Blotting, Western
Catalysis
Cells, Cultured
Constitutive Androstane Receptor
Cytochrome P-450 CYP2B6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--biosynthesis
DNA--biosynthesis
Dipyrone--analogs & derivatives
Dose-Response Relationship, Drug
Enzyme Induction--drug effects
Female
Genotype
Hepatocytes--drug effects
Humans
In Vitro Techniques
Isoenzymes--metabolism
Liver--drug effects
Male
Microsomes, Liver--drug effects
Middle Aged
Oxidoreductases, N-Demethylating--biosynthesis
Plasmids
Pregnane X Receptor
RNA--biosynthesis
Receptors, Cytoplasmic and Nuclear--drug effects
Receptors, Steroid--drug effects
Reverse Transcriptase Polymerase Chain Reaction
Transcription Factors--drug effects