Hinke, S A <br/><br/>
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.  [electronic resource] 

 -  British journal of pharmacology  Apr 2007 
 - 1031-43 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0007-1188 
<br/><br/><label>Standard No.: </label>10.1038/sj.bjp.0707189  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>AMP-Activated Protein Kinases<br/>Animals<br/>Apoptosis--drug effects<br/>Biguanides--antagonists & inhibitors<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Dose-Response Relationship, Drug<br/>Electron Transport--drug effects<br/>Electron Transport Complex I--antagonists & inhibitors<br/>Electron Transport Complex II--drug effects<br/>Enzyme Activation--drug effects<br/>Glucose--metabolism<br/>Hypoglycemic Agents--antagonists & inhibitors<br/>Insulin-Secreting Cells--drug effects<br/>Metformin--toxicity<br/>Mice<br/>Mitochondria--drug effects<br/>Multienzyme Complexes--metabolism<br/>NADP--metabolism<br/>Oxidation-Reduction<br/>Phenformin--toxicity<br/>Phosphorylation--drug effects<br/>Protein Serine-Threonine Kinases--metabolism<br/>Rats<br/>Succinates--metabolism<br/>Tetrazolium Salts--metabolism<br/>Thiazoles--metabolism<br/>Time Factors