Francis, Heather

H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. [electronic resource] - Laboratory investigation; a journal of technical methods and pathology May 2007 - 473-87 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

0023-6837

10.1038/labinvest.3700533 doi


Animals
Bile Ducts--surgery
Bile Ducts, Intrahepatic--drug effects
Cell Proliferation--drug effects
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinases
Disease Models, Animal
Down-Regulation--drug effects
Drug Therapy, Combination
Gene Expression Regulation, Enzymologic--drug effects
Histamine--pharmacology
Histamine Agonists--pharmacology
Hyperplasia--chemically induced
Ligation
Liver--drug effects
MAP Kinase Signaling System
Male
Methylhistamines--pharmacology
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Mitogen-Activated Protein Kinases--metabolism
Phosphorylation
Piperidines--pharmacology
Protein Serine-Threonine Kinases--metabolism
Rats
Rats, Inbred F344
Receptor, EphA8--metabolism
Receptors, Histamine H3--genetics