Modifying the sugar moieties of daunorubicin overcomes P-gp-mediated multidrug resistance. [electronic resource]
- Molecular pharmaceutics
- 140-53 p. digital
Publication Type: Journal Article
1543-8384
10.1021/mp060075v doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors ATP-Binding Cassette Transporters--chemistry Bacterial Proteins--chemistry Carbohydrate Metabolism Cyclosporine--pharmacology Cytotoxicity, Immunologic Daunorubicin--analogs & derivatives Disaccharides--metabolism Drug Resistance, Multiple Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Humans Inhibitory Concentration 50 K562 Cells Monosaccharides--metabolism Protein Structure, Secondary