TY  - GEN
AU  - Stauffer,Shaun R
AU  - Stanton,Matthew G
AU  - Gregro,Alison R
AU  - Steinbeiser,Melissa A
AU  - Shaffer,Jennifer R
AU  - Nantermet,Philippe G
AU  - Barrow,James C
AU  - Rittle,Kenneth E
AU  - Collusi,Dennis
AU  - Espeseth,Amy S
AU  - Lai,Ming-Tain
AU  - Pietrak,Beth L
AU  - Holloway,M Katharine
AU  - McGaughey,Georgia B
AU  - Munshi,Sanjeev K
AU  - Hochman,Jerome H
AU  - Simon,Adam J
AU  - Selnick,Harold G
AU  - Graham,Samuel L
AU  - Vacca,Joseph P
TI  - Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation
SN  - 0960-894X
PY  - 2007///0529
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Baculoviridae
KW  - drug effects
KW  - Biological Availability
KW  - Cells, Cultured
KW  - Enzyme Inhibitors
KW  - chemical synthesis
KW  - Magnetic Resonance Spectroscopy
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Weight
KW  - Niacinamide
KW  - Rats
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2006.12.051
ER  -