Stauffer, Shaun R <br/><br/>
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Mar 2007 
 - 1788-92 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0960-894X 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2006.12.051  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Animals<br/>Aspartic Acid Endopeptidases--antagonists & inhibitors<br/>Baculoviridae--drug effects<br/>Biological Availability<br/>Cells, Cultured<br/>Enzyme Inhibitors--chemical synthesis<br/>Magnetic Resonance Spectroscopy<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Weight<br/>Niacinamide--chemical synthesis<br/>Rats<br/>Structure-Activity Relationship