TY  - GEN
AU  - Barnes,D J
AU  - De,S
AU  - van Hensbergen,P
AU  - Moravcsik,E
AU  - Melo,J V
TI  - Different target range and cytotoxic specificity of adaphostin and 17-allylamino-17-demethoxygeldanamycin in imatinib-resistant and sensitive cell lines
SN  - 0887-6924
PY  - 2007///0413
KW  - Adamantane
KW  - adverse effects
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Benzamides
KW  - Benzoquinones
KW  - Cell Line, Transformed
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Clone Cells
KW  - Drug Resistance, Neoplasm
KW  - Drug Screening Assays, Antitumor
KW  - Fusion Proteins, bcr-abl
KW  - antagonists & inhibitors
KW  - Gene Expression Regulation, Leukemic
KW  - Genes, abl
KW  - HSP90 Heat-Shock Proteins
KW  - physiology
KW  - Humans
KW  - Hydrogen Peroxide
KW  - Hydroquinones
KW  - Imatinib Mesylate
KW  - Lactams, Macrocyclic
KW  - Mice
KW  - Mutant Proteins
KW  - genetics
KW  - Mutation, Missense
KW  - Oxidative Stress
KW  - Piperazines
KW  - Point Mutation
KW  - Protein Kinase Inhibitors
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins c-akt
KW  - biosynthesis
KW  - Proto-Oncogene Proteins c-bcr
KW  - Pyrimidines
KW  - Reactive Oxygen Species
KW  - Recombinant Fusion Proteins
KW  - STAT5 Transcription Factor
KW  - Signal Transduction
KW  - Substrate Specificity
KW  - Transfection
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/sj.leu.2404533
ER  -