Juang, Shin-Hun <br/><br/>
D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation.  [electronic resource] 

 -  Molecular cancer therapeutics  Jan 2007 
 - 193-202 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1535-7163 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-06-0482  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Ataxia Telangiectasia Mutated Proteins<br/>Carcinoma, Renal Cell--pathology<br/>Cell Cycle Proteins--metabolism<br/>DNA Adducts--drug effects<br/>DNA Damage<br/>DNA-Binding Proteins--metabolism<br/>Drug Resistance, Neoplasm--drug effects<br/>Enzyme Activation--drug effects<br/>Flow Cytometry<br/>HT29 Cells<br/>HeLa Cells<br/>Heterocyclic Compounds, 3-Ring--pharmacology<br/>Humans<br/>Male<br/>Mice<br/>Mice, Nude<br/>Organoselenium Compounds--pharmacology<br/>Protein Kinase C--metabolism<br/>Protein Kinase C beta<br/>Protein Kinase C-alpha--metabolism<br/>Protein Serine-Threonine Kinases--metabolism<br/>Pyrroles--pharmacology<br/>Reactive Oxygen Species--metabolism<br/>S Phase--drug effects<br/>Signal Transduction--drug effects<br/>Tumor Suppressor Proteins--metabolism<br/>Xenograft Model Antitumor Assays