Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. [electronic resource]
- Leukemia Mar 2007
- 427-38 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0887-6924
10.1038/sj.leu.2404523 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism Acute Disease Adult Aged Aged, 80 and over Androstadienes--pharmacology Bone Neoplasms--pathology Cell Line, Tumor--drug effects Drug Resistance, Neoplasm--genetics Female Fluorescent Dyes--metabolism Gene Expression Regulation, Leukemic--drug effects Genes, p53 Humans Jurkat Cells--drug effects Leukemia, Myeloid--genetics Leukemia, Promyelocytic, Acute--pathology Leukemia-Lymphoma, Adult T-Cell--pathology Leukocytes, Mononuclear--drug effects Male Middle Aged Multidrug Resistance-Associated Proteins--biosynthesis Neoplasm Proteins--biosynthesis Neoplastic Stem Cells--drug effects Osteosarcoma--pathology Phosphatidylinositol 3-Kinases--physiology Phosphoinositide-3 Kinase Inhibitors Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt--physiology Proto-Oncogene Proteins c-mdm2--biosynthesis Rhodamine 123--metabolism Tumor Suppressor Protein p53--biosynthesis Wortmannin