TY - GEN AU - Abe,Kohtaro AU - Tawara,Shunsuke AU - Oi,Keiji AU - Hizume,Takatoshi AU - Uwatoku,Toyokazu AU - Fukumoto,Yoshihiro AU - Kaibuchi,Kozo AU - Shimokawa,Hiroaki TI - Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice SN - 0160-2446 PY - 2007///0618 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - analogs & derivatives KW - Animals KW - Arterioles KW - drug effects KW - Blotting, Western KW - Disease Models, Animal KW - Hypertension, Pulmonary KW - physiopathology KW - Hypertrophy, Right Ventricular KW - Hypoxia KW - Intracellular Signaling Peptides and Proteins KW - antagonists & inhibitors KW - Lung KW - blood supply KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Nitric Oxide Synthase Type III KW - deficiency KW - Phosphorylation KW - Protein Kinase Inhibitors KW - pharmacology KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - metabolism KW - Time Factors KW - Up-Regulation KW - rho-Associated Kinases N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1097/01.fjc.0000248244.64430.4a ER -