Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. [electronic resource]
- Journal of cardiovascular pharmacology Dec 2006
- 280-5 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0160-2446
10.1097/01.fjc.0000248244.64430.4a doi
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine--analogs & derivatives Animals Arterioles--drug effects Blotting, Western Disease Models, Animal Hypertension, Pulmonary--physiopathology Hypertrophy, Right Ventricular--physiopathology Hypoxia--physiopathology Intracellular Signaling Peptides and Proteins--antagonists & inhibitors Lung--blood supply Male Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type III--deficiency Phosphorylation--drug effects Protein Kinase Inhibitors--pharmacology Protein Serine-Threonine Kinases--antagonists & inhibitors Proto-Oncogene Proteins c-akt--metabolism Time Factors Up-Regulation--drug effects rho-Associated Kinases