TY - GEN AU - Deming,Damon AU - Sheahan,Timothy AU - Heise,Mark AU - Yount,Boyd AU - Davis,Nancy AU - Sims,Amy AU - Suthar,Mehul AU - Harkema,Jack AU - Whitmore,Alan AU - Pickles,Raymond AU - West,Ande AU - Donaldson,Eric AU - Curtis,Kristopher AU - Johnston,Robert AU - Baric,Ralph TI - Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants SN - 1549-1676 PY - 2007///0215 KW - Aging KW - physiology KW - Animals KW - Disease Models, Animal KW - Disease Outbreaks KW - Encephalitis Virus, Venezuelan Equine KW - immunology KW - Enzyme-Linked Immunosorbent Assay KW - Female KW - Hemagglutinins, Viral KW - Immunity, Cellular KW - Lung KW - pathology KW - Membrane Glycoproteins KW - Mice KW - Mice, Inbred BALB C KW - Molecular Sequence Data KW - Neutralization Tests KW - Nucleocapsid Proteins KW - Replicon KW - Severe acute respiratory syndrome-related coronavirus KW - Spike Glycoprotein, Coronavirus KW - Treatment Outcome KW - Viral Envelope Proteins KW - Viral Vaccines KW - Zoonoses KW - virology N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1371/journal.pmed.0030525 ER -