Caraglia, Michele <br/><br/>
R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation.  [electronic resource] 

 -  Journal of cellular physiology  May 2007 
 - 533-43 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9541 
<br/><br/><label>Standard No.: </label>10.1002/jcp.20960  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenocarcinoma--drug therapy<br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--metabolism<br/>Caspases--metabolism<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Diphosphonates--pharmacology<br/>Dose-Response Relationship, Drug<br/>Drug Synergism<br/>Enzyme Activation--drug effects<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Humans<br/>Imidazoles--pharmacology<br/>Male<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Phosphorylation--drug effects<br/>Prostatic Neoplasms--drug therapy<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Proto-Oncogene Proteins c-bcl-2--metabolism<br/>Quinolones--pharmacology<br/>Signal Transduction--drug effects<br/>Time Factors<br/>Xenograft Model Antitumor Assays<br/>Zoledronic Acid<br/>bcl-Associated Death Protein--metabolism<br/>ras Proteins--metabolism