TY  - GEN
AU  - Sun,Haiying
AU  - Nikolovska-Coleska,Zaneta
AU  - Lu,Jianfeng
AU  - Qiu,Su
AU  - Yang,Chao-Yie
AU  - Gao,Wei
AU  - Meagher,Jennifer
AU  - Stuckey,Jeanne
AU  - Wang,Shaomeng
TI  - Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic
SN  - 0022-2623
PY  - 2007///0202
KW  - Azepines
KW  - chemical synthesis
KW  - Baculoviral IAP Repeat-Containing 3 Protein
KW  - Binding, Competitive
KW  - Breast Neoplasms
KW  - metabolism
KW  - Caspase 3
KW  - Caspase 9
KW  - Caspase Inhibitors
KW  - Cell Death
KW  - drug effects
KW  - Cell Membrane Permeability
KW  - Cell Proliferation
KW  - Enzyme Activation
KW  - Heterocyclic Compounds
KW  - Humans
KW  - Inhibitor of Apoptosis Proteins
KW  - Mitochondria
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Mimicry
KW  - Protein Binding
KW  - Pyrrolidines
KW  - Structure-Activity Relationship
KW  - Tumor Cells, Cultured
KW  - Ubiquitin-Protein Ligases
KW  - X-Linked Inhibitor of Apoptosis Protein
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm061108d
ER  -