Sun, Haiying <br/><br/>
Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.  [electronic resource] 

 -  Journal of medicinal chemistry  Dec 2006 
 - 7916-20 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm061108d  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Azepines--chemical synthesis<br/>Baculoviral IAP Repeat-Containing 3 Protein<br/>Binding, Competitive<br/>Breast Neoplasms--metabolism<br/>Caspase 3--metabolism<br/>Caspase 9--metabolism<br/>Caspase Inhibitors<br/>Cell Death--drug effects<br/>Cell Membrane Permeability<br/>Cell Proliferation--drug effects<br/>Enzyme Activation--drug effects<br/>Heterocyclic Compounds--chemical synthesis<br/>Humans<br/>Inhibitor of Apoptosis Proteins--metabolism<br/>Mitochondria--drug effects<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Mimicry<br/>Protein Binding<br/>Pyrrolidines--chemical synthesis<br/>Structure-Activity Relationship<br/>Tumor Cells, Cultured<br/>Ubiquitin-Protein Ligases<br/>X-Linked Inhibitor of Apoptosis Protein--metabolism