TY - GEN AU - Cai,Ying AU - Martens,Geert A AU - Hinke,Simon A AU - Heimberg,Harry AU - Pipeleers,Daniel AU - Van de Casteele,Mark TI - Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation SN - 0891-5849 PY - 2007///0215 KW - AMP-Activated Protein Kinases KW - Aminoimidazole Carboxamide KW - analogs & derivatives KW - Animals KW - Apoptosis KW - physiology KW - Blotting, Western KW - Caspase 3 KW - metabolism KW - Cell Line KW - Enzyme Activation KW - Enzyme Inhibitors KW - pharmacology KW - Glucose KW - Hydrogen Peroxide KW - Hypoglycemic Agents KW - Insulin KW - Insulin-Secreting Cells KW - JNK Mitogen-Activated Protein Kinases KW - Mice KW - Mitochondria KW - Multienzyme Complexes KW - Palmitates KW - Phosphorylation KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-bcl-2 KW - RNA, Messenger KW - genetics KW - Rats KW - Reactive Oxygen Species KW - Reverse Transcriptase Polymerase Chain Reaction KW - Ribonucleotides N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.freeradbiomed.2006.09.018 ER -