Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. [electronic resource]
- The Journal of experimental medicine Dec 2006
- 2829-40 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1007
10.1084/jem.20060967 doi
Adaptor Proteins, Signal Transducing--genetics Adoptive Transfer Animals B-Lymphocytes--drug effects Benzamides Cell Differentiation--drug effects Cell Line Cell Proliferation--drug effects DNA-Binding Proteins--genetics Fusion Proteins, bcr-abl--antagonists & inhibitors Humans Imatinib Mesylate Intercellular Signaling Peptides and Proteins--pharmacology Intracellular Signaling Peptides and Proteins--antagonists & inhibitors Leukemia--genetics Mice Mice, Inbred BALB C Mice, Knockout Oxazines--pharmacology Phospholipase C gamma--genetics Phosphorylation--drug effects Piperazines--pharmacology Protein Kinase Inhibitors--pharmacology Protein-Tyrosine Kinases--antagonists & inhibitors Proto-Oncogene Proteins c-myc--genetics Pyridines--pharmacology Pyrimidines--pharmacology Receptors, Antigen, B-Cell--genetics Spleen--drug effects Syk Kinase Transfection