Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin. [electronic resource]
- Biochemistry Nov 2006
- 14003-11 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
0006-2960
10.1021/bi0614277 doi
Amino Acid Sequence Animals Arachidonic Acid--metabolism Base Sequence Catalysis Cell Line Cytochrome P-450 Enzyme System--chemistry DNA Primers Epoprostenol--metabolism Humans Intramolecular Oxidoreductases--chemistry Prostaglandin-Endoperoxide Synthases--chemistry Protein Engineering Recombinant Proteins--chemistry Substrate Specificity