PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax. [electronic resource]
- Biochemical and biophysical research communications Jan 2007
- 203-12 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-291X
10.1016/j.bbrc.2006.11.006 doi
Apoptosis--drug effects Apoptosis Regulatory Proteins--genetics Aza Compounds--pharmacology Binding Sites Bridged Bicyclo Compounds, Heterocyclic--pharmacology Cell Line, Tumor Extracellular Signal-Regulated MAP Kinases--genetics Humans Intracellular Signaling Peptides and Proteins JNK Mitogen-Activated Protein Kinases--metabolism Mutation--genetics Phosphorylation Promoter Regions, Genetic--genetics Protein Binding Protein Serine-Threonine Kinases--genetics Proto-Oncogene Proteins--genetics Signal Transduction Tumor Suppressor Protein p53--genetics bcl-2-Associated X Protein--genetics