TY - GEN AU - Solinas,Giovanni AU - Naugler,Willscott AU - Galimi,Francesco AU - Lee,Myung-Shik AU - Karin,Michael TI - Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates SN - 0027-8424 PY - 2006///1222 KW - Amino Acid Sequence KW - Animals KW - Blood Glucose KW - metabolism KW - Cells, Cultured KW - Enzyme Activation KW - Fatty Acids KW - Gene Expression Regulation KW - Hepatocytes KW - drug effects KW - Humans KW - Insulin KW - genetics KW - Insulin Receptor Substrate Proteins KW - Insulin Resistance KW - Intracellular Signaling Peptides and Proteins KW - chemistry KW - Male KW - Mice KW - Mitogen-Activated Protein Kinase 8 KW - deficiency KW - Obesity KW - Palmitic Acid KW - pharmacology KW - Phosphoproteins KW - Phosphorylation KW - Rats KW - Substrate Specificity KW - Transcription, Genetic N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1073/pnas.0607626103 ER -