Pore, Nabendu

Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. [electronic resource] - Cancer research Sep 2006 - 9252-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0008-5472

10.1158/0008-5472.CAN-06-1239 doi


Animals
Carcinoma, Squamous Cell--blood supply
Cell Line, Tumor
Down-Regulation--drug effects
Female
Head and Neck Neoplasms--blood supply
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--biosynthesis
Lung Neoplasms--drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Nelfinavir--pharmacology
Neovascularization, Pathologic--drug therapy
Oxygen--metabolism
Protease Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Radiation Tolerance--drug effects
Random Allocation
Sp1 Transcription Factor--metabolism
Vascular Endothelial Growth Factor A--biosynthesis
Xenograft Model Antitumor Assays