Fernandez-Gomez, F J <br/><br/>
Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.  [electronic resource] 

 -  Neurobiology of disease  Nov 2006 
 - 296-307 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0969-9961 
<br/><br/><label>Standard No.: </label>10.1016/j.nbd.2006.07.005  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Animals, Newborn<br/>Antioxidants--metabolism<br/>Apoptosis--drug effects<br/>Cells, Cultured<br/>Cerebellar Cortex--drug effects<br/>Cytoprotection--drug effects<br/>Dose-Response Relationship, Drug<br/>Extracellular Signal-Regulated MAP Kinases--drug effects<br/>Glutathione Peroxidase--drug effects<br/>Lipid Peroxidation--drug effects<br/>Nerve Degeneration--drug therapy<br/>Neurons--drug effects<br/>Neuroprotective Agents--metabolism<br/>Neurotoxins--antagonists & inhibitors<br/>Oxidative Stress--drug effects<br/>Oxidopamine--antagonists & inhibitors<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Proto-Oncogene Proteins c-akt--drug effects<br/>Pyruvic Acid--metabolism<br/>RNA, Messenger--drug effects<br/>Rats<br/>Signal Transduction--drug effects<br/>Up-Regulation--drug effects