DiMauro, Erin F <br/><br/>
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.  [electronic resource] 

 -  Journal of medicinal chemistry  Sep 2006 
 - 5671-86 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm0605482  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis<br/>Benzamides--chemical synthesis<br/>Biological Availability<br/>Cell Proliferation--drug effects<br/>Cells, Cultured<br/>Female<br/>Humans<br/>In Vitro Techniques<br/>Interleukin-2--biosynthesis<br/>Lymphocyte Specific Protein Tyrosine Kinase p56(lck)--antagonists & inhibitors<br/>Male<br/>Mice<br/>Mice, Inbred BALB C<br/>Models, Molecular<br/>Quinazolines--chemical synthesis<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>T-Lymphocytes--cytology<br/>Tumor Necrosis Factor-alpha--biosynthesis