Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). [electronic resource]
- Life sciences Nov 2006
- 2480-5 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0024-3205
10.1016/j.lfs.2006.08.008 doi
Anthracenes--pharmacology Blotting, Western Cells, Cultured Dose-Response Relationship, Drug Emodin--pharmacology Fibroblasts--cytology Flavonoids--pharmacology Humans Imidazoles--pharmacology Infant, Newborn JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Luciferases--genetics Male Matrix Metalloproteinase 1--biosynthesis Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3--antagonists & inhibitors Phosphorylation--drug effects Promoter Regions, Genetic--genetics Pyridines--pharmacology Rheum--chemistry Transcription Factor AP-1--antagonists & inhibitors Transfection Tumor Necrosis Factor-alpha--pharmacology p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors