TY  - GEN
AU  - Braselmann,Sylvia
AU  - Taylor,Vanessa
AU  - Zhao,Haoran
AU  - Wang,Su
AU  - Sylvain,Catherine
AU  - Baluom,Muhammad
AU  - Qu,Kunbin
AU  - Herlaar,Ellen
AU  - Lau,Angela
AU  - Young,Chi
AU  - Wong,Brian R
AU  - Lovell,Scott
AU  - Sun,Thomas
AU  - Park,Gary
AU  - Argade,Ankush
AU  - Jurcevic,Stipo
AU  - Pine,Polly
AU  - Singh,Rajinder
AU  - Grossbard,Elliott B
AU  - Payan,Donald G
AU  - Masuda,Esteban S
TI  - R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
SN  - 0022-3565
PY  - 2007///0109
KW  - Animals
KW  - Antigen-Antibody Complex
KW  - physiology
KW  - Arthritis, Experimental
KW  - pathology
KW  - Arthus Reaction
KW  - physiopathology
KW  - B-Lymphocytes
KW  - drug effects
KW  - Basophils
KW  - Blotting, Western
KW  - Cells, Cultured
KW  - Crystallography
KW  - Double-Blind Method
KW  - Enzyme Inhibitors
KW  - pharmacokinetics
KW  - Fluorescence Polarization Immunoassay
KW  - Humans
KW  - Immunoglobulin G
KW  - biosynthesis
KW  - Inflammation
KW  - drug therapy
KW  - Lipopolysaccharides
KW  - pharmacology
KW  - Macrophages
KW  - Mast Cells
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Oxazines
KW  - Platelet Aggregation
KW  - Protein-Tyrosine Kinases
KW  - antagonists & inhibitors
KW  - Pyridines
KW  - Receptors, Fc
KW  - Signal Transduction
KW  - Spleen
KW  - enzymology
KW  - Stimulation, Chemical
KW  - Tetradecanoylphorbol Acetate
N1  - Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/jpet.106.109058
ER  -