Martin, Matthew W <br/><br/>
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.  [electronic resource] 

 -  Journal of medicinal chemistry  Aug 2006 
 - 4981-91 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm060435i  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Aminopyridines--chemical synthesis<br/>Animals<br/>Anti-Inflammatory Agents--chemical synthesis<br/>Biological Availability<br/>Carbamates--chemical synthesis<br/>Crystallography, X-Ray<br/>Humans<br/>In Vitro Techniques<br/>Jurkat Cells<br/>Lymphocyte Activation<br/>Lymphocyte Culture Test, Mixed<br/>Lymphocyte Specific Protein Tyrosine Kinase p56(lck)--antagonists & inhibitors<br/>Mice<br/>Mice, Inbred BALB C<br/>Models, Molecular<br/>Molecular Structure<br/>Pyrimidines--chemical synthesis<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>T-Lymphocytes--drug effects