Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Oct 2006
- 1756-63 p. digital
Publication Type: Journal Article
0090-9556
10.1124/dmd.106.010033 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters--genetics Adult Constitutive Androstane Receptor Gene Expression Regulation--drug effects Hepatocytes--cytology Humans Membrane Transport Proteins--genetics Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins--genetics NF-E2-Related Factor 2--genetics Neoplasm Proteins--genetics Phenobarbital--pharmacology Polychlorinated Dibenzodioxins--pharmacology Pregnane X Receptor Pyrazines--pharmacology RNA, Messenger--genetics Receptors, Aryl Hydrocarbon--drug effects Receptors, Cytoplasmic and Nuclear--genetics Receptors, Drug--genetics Receptors, Steroid--genetics Reverse Transcriptase Polymerase Chain Reaction--methods Rifampin--pharmacology Symporters--genetics Thiones Thiophenes Transcription Factors--genetics Xenobiotics--pharmacology