TY  - GEN
AU  - Pikman,Yana
AU  - Lee,Benjamin H
AU  - Mercher,Thomas
AU  - McDowell,Elizabeth
AU  - Ebert,Benjamin L
AU  - Gozo,Maricel
AU  - Cuker,Adam
AU  - Wernig,Gerlinde
AU  - Moore,Sandra
AU  - Galinsky,Ilene
AU  - DeAngelo,Daniel J
AU  - Clark,Jennifer J
AU  - Lee,Stephanie J
AU  - Golub,Todd R
AU  - Wadleigh,Martha
AU  - Gilliland,D Gary
AU  - Levine,Ross L
TI  - MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
SN  - 1549-1676
PY  - 2007///0212
KW  - Amino Acid Substitution
KW  - Animals
KW  - Bone Marrow Cells
KW  - drug effects
KW  - Bone Marrow Transplantation
KW  - Cell Division
KW  - Cells, Cultured
KW  - Colony-Forming Units Assay
KW  - Cytokines
KW  - pharmacology
KW  - Disease Models, Animal
KW  - Gene Expression Regulation
KW  - Genetic Vectors
KW  - Hematologic Neoplasms
KW  - drug therapy
KW  - Hematopoiesis
KW  - genetics
KW  - Humans
KW  - Janus Kinases
KW  - antagonists & inhibitors
KW  - Megakaryocytes
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mutation, Missense
KW  - Myeloid Cells
KW  - Myeloproliferative Disorders
KW  - etiology
KW  - Oncogene Proteins, Fusion
KW  - Phosphorylation
KW  - Point Mutation
KW  - Primary Myelofibrosis
KW  - Protein Kinase Inhibitors
KW  - Protein Processing, Post-Translational
KW  - Receptor, Platelet-Derived Growth Factor alpha
KW  - Receptors, Cytokine
KW  - physiology
KW  - Recombinant Fusion Proteins
KW  - adverse effects
KW  - STAT Transcription Factors
KW  - Sequence Analysis, DNA
KW  - Signal Transduction
KW  - Spleen
KW  - pathology
KW  - Thrombocytosis
KW  - Transcription, Genetic
KW  - mRNA Cleavage and Polyadenylation Factors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pmed.0030270
ER  -