MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. [electronic resource]
- PLoS medicine Jul 2006
- e270 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1549-1676
10.1371/journal.pmed.0030270 doi
Amino Acid Substitution Animals Bone Marrow Cells--drug effects Bone Marrow Transplantation Cell Division--drug effects Cells, Cultured--drug effects Colony-Forming Units Assay Cytokines--pharmacology Disease Models, Animal Gene Expression Regulation Genetic Vectors Hematologic Neoplasms--drug therapy Hematopoiesis--genetics Humans Janus Kinases--antagonists & inhibitors Megakaryocytes--drug effects Mice Mice, Inbred BALB C Mutation, Missense Myeloid Cells--drug effects Myeloproliferative Disorders--etiology Oncogene Proteins, Fusion--genetics Phosphorylation--drug effects Point Mutation Primary Myelofibrosis--genetics Protein Kinase Inhibitors--pharmacology Protein Processing, Post-Translational--drug effects Receptor, Platelet-Derived Growth Factor alpha--genetics Receptors, Cytokine--physiology Recombinant Fusion Proteins--adverse effects STAT Transcription Factors--physiology Sequence Analysis, DNA Signal Transduction--genetics Spleen--pathology Thrombocytosis--etiology Transcription, Genetic mRNA Cleavage and Polyadenylation Factors--genetics