TY  - GEN
AU  - Hirsh,Andrew J
AU  - Molino,Bruce F
AU  - Zhang,Jianzhong
AU  - Astakhova,Nadezhda
AU  - Geiss,William B
AU  - Sargent,Bruce J
AU  - Swenson,Brian D
AU  - Usyatinsky,Alexander
AU  - Wyle,Michael J
AU  - Boucher,Richard C
AU  - Smith,Rick T
AU  - Zamurs,Andra
AU  - Johnson,M Ross
TI  - Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis
SN  - 0022-2623
PY  - 2006///0911
KW  - Animals
KW  - Bronchi
KW  - drug effects
KW  - Bronchitis, Chronic
KW  - drug therapy
KW  - Combinatorial Chemistry Techniques
KW  - Cystic Fibrosis
KW  - Dogs
KW  - Epithelial Sodium Channels
KW  - Guanidines
KW  - chemical synthesis
KW  - Models, Molecular
KW  - Pyrazines
KW  - Respiratory Mucosa
KW  - Sodium Channel Blockers
KW  - Sodium Channels
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Tissue Culture Techniques
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm051134w
ER  -